Cyclodextrin-Polypyrrole Coatings of Scaffolds for Tissue Engineering
| Autor: | Kateřina Strnadová, Jan Lukášek, Karel Mašek, Kristýna Havlíčková, Sarka Hauzerova, Věra Jenčová, Michal Řezanka, Ivan Stibor, Martin Stuchlík |
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| Rok vydání: | 2019 |
| Předmět: |
Conductive polymer
chemistry.chemical_classification Scaffold Materials science Polymers and Plastics Cyclodextrin Biomolecule Nanotechnology General Chemistry Adhesion scaffold Polypyrrole lcsh:QD241-441 chemistry.chemical_compound functionalisation lcsh:Organic chemistry chemistry Tissue engineering cyclodextrin polypyrrole pyrrole polycaprolactone tissue engineering Polycaprolactone microfibres |
| Zdroj: | Polymers Volume 11 Issue 3 Polymers, Vol 11, Iss 3, p 459 (2019) |
| ISSN: | 2073-4360 |
| Popis: | Polypyrrole is one of the most investigated conductive polymers used for tissue engineering applications because of its advantageous properties and the ability to promote different cell types&rsquo adhesion and proliferation. Together with &beta cyclodextrin, which is capable of accommodating helpful biomolecules in its cavity, it would make a perfect couple for use as a scaffold for tissue engineering. Such scaffolds were prepared by the polymerisation of 6-(pyrrol-3-yl)hexanoic acid on polycaprolactone microfibres with subsequent attachment of &beta cyclodextrin on the polypyrrole layer. The materials were deeply characterised by several physical and spectroscopic techniques. Testing of the cyclodextrin enriched composite scaffold revealed its better performance in in vitro experiments compared with pristine polycaprolactone or polypyrrole covered polycaprolactone scaffolds. |
| Databáze: | OpenAIRE |
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