Effect of Ascorbic Acid Supplementation on Certain Oxidative Stress Parameters in the Post Reperfusion Patients of Myocardial Infarction
| Autor: | M. K. Misra, Pushpa Bhakuni, M. Chandra |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Xanthine Oxidase
medicine.medical_specialty Antioxidant medicine.medical_treatment Clinical Biochemistry Myocardial Infarction Myocardial Reperfusion Ascorbic Acid medicine.disease_cause Superoxide dismutase chemistry.chemical_compound Malondialdehyde Internal medicine medicine Humans Xanthine oxidase Molecular Biology Vitamin C biology Superoxide Dismutase Chemistry Cell Biology General Medicine medicine.disease Ascorbic acid Surgery Oxidative Stress Endocrinology Reperfusion biology.protein Reactive Oxygen Species Reperfusion injury Oxidative stress |
| Zdroj: | Molecular and Cellular Biochemistry. 290:153-158 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/s11010-006-9182-y |
| Popis: | Reperfusion injury causes oxidative stress thereby resulting in an imbalance between oxidant-antioxidant systems. In the present communication, the effect of ascorbic acid supplementation has been studied on certain oxidant and antioxidant parameters in the blood of the patients with myocardial infarction before and after thrombolysis. In patients after thrombolysis, the activity of antioxidant enzyme, superoxide dismutase, in the blood was found to be significantly reduced where as the activity of the oxidant enzyme, xanthine oxidase, was found to be significantly increased. Malondialdehyde levels, the index of free radical mediated damage, was also found to be significantly elevated in thrombolysed patients compared to the patients before thrombolysis. Supplementation of vitamin C to the post reperfusion patients restored these parameters back to normal or near normal levels. |
| Databáze: | OpenAIRE |
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