The Role of the IL-33/ST2 Immune Pathway in Autoimmunity: New Insights and Perspectives
| Autor: | Hamed Mohammadi, Maryam Hemmatzadeh, Farhad Jadidi-Niaragh, Fatemeh Ezzatifar, Farhad Babaie, Saeed Aslani, Arezoo Gowhari-Shabgah, Fatemeh Sadat Mohammadi, Faezeh Ramezani |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
animal diseases medicine.medical_treatment Immunology Cell Autoimmunity chemical and pharmacologic phenomena medicine.disease_cause Autoimmune Diseases 03 medical and health sciences 0302 clinical medicine Immune system Humans Medicine business.industry Interleukin General Medicine biochemical phenomena metabolism and nutrition Interleukin-33 Interleukin-1 Receptor-Like 1 Protein Endothelial stem cell Interleukin 33 030104 developmental biology medicine.anatomical_structure Cytokine 030220 oncology & carcinogenesis Cytokines bacteria business Signal Transduction |
| Zdroj: | Immunological Investigations. 51:1060-1086 |
| ISSN: | 1532-4311 0882-0139 |
| DOI: | 10.1080/08820139.2021.1878212 |
| Popis: | Interleukin (IL)-33, a member of IL-1 cytokine family, is produced by various immune cells and acts as an alarm to alert the immune system after epithelial or endothelial cell damage during cell necrosis, infection, stress, and trauma. The biological functions of IL-33 largely depend on its ligation to the corresponding receptor, suppression of tumorigenicity 2 (ST2). The pathogenic roles of this cytokine have been implicated in several disorders, including allergic disease, cardiovascular disease, autoimmune disease, infectious disease, and cancers. However, alerted levels of IL-33 may result in either disease amelioration or progression. Genetic variations of |
| Databáze: | OpenAIRE |
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