Duration of action of formoterol and salbutamol dry-powder inhalation in prevention of exercise-induced asthma in children
| Autor: | Hans Bisgaard, Kim G. Nielsen, Marianne Skov, Peer Daugbjerg |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Time Factors Adolescent medicine.drug_class Placebo Double-Blind Method Forced Expiratory Volume Formoterol Fumarate Bronchodilator Administration Inhalation medicine Humans Albuterol Child Asthma Exercise-induced asthma Cross-Over Studies business.industry Nebulizers and Vaporizers Inhaler General Medicine medicine.disease Bronchodilator Agents respiratory tract diseases Asthma Exercise-Induced Ethanolamines Anesthesia Pediatrics Perinatology and Child Health Exercise Test Salbutamol Female Formoterol Powders business medicine.drug |
| Zdroj: | Acta Paediatrica. 85:684-687 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1996.tb14125.x |
| Popis: | The aim of this study was to evaluate the effect and tolerability of formoterol 12 μg on exercise-induced asthma in children for 12 h as compared to the effect of salbutamol 400 μg and placebo. The drugs were inhaled as dry powder from a flow-dependent metered-dose inhaler (DP-MDI). Sixteen asthmatic children took part in a double-blind placebo-controlled within-patient single-centre trial. On each study day the patients were given one of the drugs or placebo in random order, and standardized exercise tests were performed after 3 and 12 h. At a pretrial test the children had demonstrated a median maximum percentage fall of 38% (range 22-79%) in forced expiratory volume in I s after exercise challenge. Formoterol showed a median percentage protection of 77% and 70% at 3 and 12h postexercise, respectively, as compared to 46% and 13% with salbutamol. No side-effects were observed. Formoterol 12 μg administered as dry powder offers significantly better protection against exercise-induced asthma after 3 and 12 h as compared to salbutamol 400 μg and placebo. Children, exercise-induced asthma, ― fortlioterol, salbutamol |
| Databáze: | OpenAIRE |
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