Chronic Wound Repair and Healing in Older Adults: Current Status and Future Research
| Autor: | William R. Hazzard, Susan J. Zieman, Jeremy D. Walston, Teresa Conner-Kerr, Luisa A. DiPietro, Dennis H. Sullivan, Jo Anne D. Whitney, Kevin P. High, Kenneth E. Schmader, Sue E. Gardner, Nasreen Jacobson, Caroline E. Fife, May J. Reed, Lisa J. Gould, Frances Mc Farland Horne, Jeffrey M. Davidson, John P. Williams, Robert S. Kirsner, Marjana Tomic-Canic, Pamela Houghton, David J. Margolis, Elizabeth J. Kovacs, John W. Harmon, Peter M. Abadir, Marissa J Carter, Vincent Falanga, Stephen R. Thom, Elizabeth A. Grice, Harold Brem |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Chronic wound Aging Canada medicine.medical_specialty Administration Topical Population Electric Stimulation Therapy Comorbidity Venous leg ulcer Article law.invention Mice Quality of life (healthcare) Anti-Infective Agents Randomized controlled trial law Skin Ulcer medicine Animals Humans Intensive care medicine education Aged Aged 80 and over Wound Healing education.field_of_study Tissue Engineering integumentary system business.industry Age Factors Skin ulcer medicine.disease United States Surgery Diabetic foot ulcer Chronic Disease Disease Progression Quality of Life Female Geriatrics and Gerontology medicine.symptom Wound healing business Negative-Pressure Wound Therapy |
| Zdroj: | Journal of the American Geriatrics Society. 63:427-438 |
| ISSN: | 0002-8614 |
| Popis: | The incidence of chronic wounds is increased among older adults, and the impact of chronic wounds on quality of life is particularly profound in this population. It is well established that wound healing slows with age. However, the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The impact of age and accompanying multi-morbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables, lack of standardization in data collection, and variations in the definition, measurement, and treatment of wounds also hamper clinical studies. The Association of Specialty Professors, in conjunction with the National Institute on Aging and the Wound Healing Society, held a workshop, summarized in this paper, to explore the current state of knowledge and research challenges, engage investigators across disciplines, and identify key research questions to guide future study of age-associated changes in chronic wound healing. |
| Databáze: | OpenAIRE |
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