Efficacy analysis of 131I therapy and predictive value of preablation stimulated thyroglobulin for lung metastases from differentiated thyroid cancer
| Autor: | Hui Wang, Shuqi Wu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Lung Neoplasms Endocrinology Diabetes and Metabolism medicine.medical_treatment Carcinoma Papillary Follicular Thyroid Function Tests Thyroglobulin Thyroid function tests Gastroenterology Iodine Radioisotopes Young Adult Endocrinology Predictive Value of Tests Internal medicine Preoperative Care Carcinoma Humans Medicine Thyroid Neoplasms Lymph node Thyroid cancer Aged Retrospective Studies Lung medicine.diagnostic_test business.industry Thyroidectomy Cell Differentiation General Medicine Middle Aged medicine.disease Combined Modality Therapy Treatment Outcome medicine.anatomical_structure Predictive value of tests Female business |
| Zdroj: | Annales d'Endocrinologie. 74:40-44 |
| ISSN: | 0003-4266 |
| Popis: | Objective Our objective was to investigate the clinical efficacy of 131 I therapy for lung metastases from differentiated thyroid cancer (DTC) and assess whether the preablation stimulated thyroglobulin (Tg) could have predictive value for the outcome. Methods and materials Fifty-two DTC patients (mean 44.5 ± 19.2 years; 33 females and 19 males) with lung metastases treated with 131 I were retrospectively analysed. The therapeutic efficacy was evaluated based on the change in serum Tg. Fifty patients’ preablation stimulated Tg were collected with negative Tg antibody levels and estimated using the t -test method. Results After 131 I therapy, a significant decrease in serum Tg was seen in 30 patients (effective rate, 57.6%), and changes in serum Tg that indicated stabilization and ineffectiveness were both seen in 11 patients (21.2%). Only patients with age under 45 years were more likely to respond to serum Tg changes ( P = 0.046). But binary logistic regression revealed that none of the six factors (age, patient gender, pathological type, local lymph node involvement, size of metastases, and 131 I uptake by metastases) had statistically significant impacts on the efficacy analysis (all P > 0.05). For analysing with the preablation stimulated Tg, the “Fine miliaric” and 131 I uptake positive with great prognosis group was much lower than any other group (all the P Conclusion 131 I therapy is a feasible and effective treatment for DTC lung metastases. A better prognosis would be accomplished in those who had low level of preablation stimulated Tg in DTC patient with lung metastases. |
| Databáze: | OpenAIRE |
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