Protoflavonoids from ferns impair centrosomal integrity of tumor cells
| Autor: | Michel Wright, Muriel Batut, Isabelle Huc-Dumas, Isabelle Pouny, Frédéric Girard, Georges Massiot, Laurence Marcourt, Chantal Etievant |
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| Rok vydání: | 2010 |
| Předmět: |
Stereochemistry
Cell Survival Pharmaceutical Science Equisetaceae Mitosis Pharmacognosy Analytical Chemistry HeLa Inhibitory Concentration 50 Tubulin Drug Discovery Phegopteris Cytotoxic T cell Humans Pharmacology Centrosome Flavonoids biology Cyclohexanones Plant Extracts Organic Chemistry biology.organism_classification Flavones Molecular biology Antineoplastic Agents Phytogenic Phenotype Complementary and alternative medicine Ferns Molecular Medicine Fern HeLa Cells |
| Zdroj: | Planta medica. 77(5) |
| ISSN: | 1439-0221 |
| Popis: | Six protoflavonoids, including two new compounds, were isolated during a large scale screening of fern extracts for original interaction with mitosis. The new compounds isolated from PHEGOPTERIS DECURSIVE-PINNATA and EQUISETUM FLUVIATILE were 2′,3′-dihydroprotogenkwanone ( 1) and 2′,3′-dihydro-2′-hydroxyprotoapigenone ( 2). Known compounds were: protoapigenone, protogenkwanone, protoapigenin, and 4′- O- β-D-glucopyranosyl protoapigenin. They showed a cytotoxic activity against HeLa cells at a micromolar level. IC 50 values were 2 µM for compound 1, > 10 µM for compound 2, and respectively 2.4, 0.6, > 10 µM for the known compounds. Their cytotoxic effects were associated with phenotypic changes never observed before and characterized by the loss of centrosomal γ-tubulin labelling in both mitotic and interphasic cells. |
| Databáze: | OpenAIRE |
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