Prolactin, cortisol secretion and thyroid function in patients with stroke of mild severity
| Autor: | Venetsana Kyriazopoulou, N. Lekka, J. Elloul, P. Taleli, Anastasia Theodoropoulou, A. G. Vagenakis, I. C. Metallinos |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cortisol secretion
Male endocrine system medicine.medical_specialty Time Factors endocrine system diseases Hydrocortisone Endocrinology Diabetes and Metabolism media_common.quotation_subject Clinical Biochemistry Thyrotropin Thyroid Function Tests Biochemistry Thyroid function tests Endocrinology TRH stimulation test Patient Admission Internal medicine medicine Post-stroke depression Humans Euthyroid Stroke Thyrotropin-Releasing Hormone media_common Aged Depressive Disorder medicine.diagnostic_test business.industry Convalescence Biochemistry (medical) General Medicine Middle Aged medicine.disease Prolactin Female Thyroid function business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 38(9) |
| ISSN: | 1439-4286 |
| Popis: | Different attempts were made to identify the variables that may be involved in the clinical course of cerebrovascular ischemia. In the case of stroke with mild severity (SMS), the clinical significance of neuroendocrine changes as well as of post-stroke depression (PSD) remains unknown. We therefore evaluated the presence of neuroendocrine changes in the acute and post-acute phase of SMS, and their potential role during convalescence. Serum cortisol, T4, T3, FT4, FT3, TSH and PRL levels were measured in 17 euthyroid patients with stroke on admission (day 1), following morning (day 2), 7 days and 3 months later. TSH and PRL secretion after TRH test were measured. Stroke severity on admission was determined by Scandinavian Stroke Scale (SSS). Montgomery-Asberg Depression Rating Scale (Madrs) was used for assessment of post-stroke depression. On admission, TSH and T3, were within normal limits and were greater compared to values on day 2. Lower basal TSH and decreased TSH response to TRH on day 2, were associated with stroke of greater severity. Delta-PRL after TRH on day 2 was higher in patients who develop PSD. Changes in serum thyroid hormones in SMS, reflects those of non-thyroidal illness. A mild stimulation of hypothalamic-pituitary-adrenal axis was detected. We provide evidence that PRL response to TRH, in the acute phase of stroke may be used as an index for early detection of PSD. |
| Databáze: | OpenAIRE |
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