Pulmonary effects of long-term β2-blockade in healthy subjects: Comparative study of metoprolol OROS
| Autor: | G. Kaik, S. Rakusan, K. Bauer |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Time Factors medicine.drug_class Adrenergic beta-Antagonists Administration Oral Blood Pressure Propranolol Placebo Heart Rate Reference Values Bronchodilator medicine Humans Plethysmograph Albuterol Lung Randomized Controlled Trials as Topic Metoprolol business.industry Airway Resistance respiratory system Atenolol Crossover study respiratory tract diseases Delayed-Action Preparations Anesthesia Salbutamol Female Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology medicine.drug |
| Zdroj: | American Heart Journal. 120:473-477 |
| ISSN: | 0002-8703 |
| Popis: | The effects on airway response of metoprolol OROS (oral osmotic) and three other long-acting beta-adrenoceptor blockers were studied. This was a placebo-controlled, randomized, five-period, single-blind, crossover trial in 15 healthy volunteers. Bronchial beta-blockade was estimated as the displacement of the salbutamol bronchodilator response of specific airway conductance (SGAW) measured by whole-body plethysmography. Metoprolol OROS (14/190 mg), slow-release (SR) metoprolol (200 mg), atenolol (100 mg), long-acting (LA) propranolol (160 mg), and placebo were given once daily for 7 days. Inhaled salbutamol was administered at peak drug levels in cumulative doses of 12.5 to 800 micrograms on day 5 and in a single dose of 400 micrograms on day 7. On day 5, salbutamol induced significant increases in SGAW in each treatment group. SGAW increased after the single dose of salbutamol on day 7 in all groups and then declined steadily. The highest values were found after placebo and metoprolol OROS, with smaller increases after SR metoprolol, atenolol, and LA propranolol, the latter showing the smallest increase. Therefore, it would appear that under steady-state conditions, beta 2-bronchial receptors are least blocked by metoprolol OROS, followed by SR metoprolol, atenolol, and LA propranolol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|