Synthesis of 3,3',5-trihydroxybiphenyl-2-carboxylic acid, a component of the bitterest natural product amarogentin and its coenzyme A and N-acetyl cysteamine thiol esters
| Autor: | Chang-Zeng Wang, Meinhart H. Zenk, Ulrich H. Maier |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Coenzyme A
Carboxylic acid Cysteamine Pharmaceutical Science Thioester Chemical synthesis Analytical Chemistry chemistry.chemical_compound Glucosides Drug Discovery Organic chemistry Iridoids Phenols Pyrans Pharmacology chemistry.chemical_classification Molecular Structure Spectrum Analysis Organic Chemistry Esters Amarogentin Complementary and alternative medicine chemistry Thiol Molecular Medicine |
| Zdroj: | Journal of natural products. 63(3) |
| ISSN: | 0163-3864 |
| Popis: | 3,3',5-Trihydroxybiphenyl-2-carboxylic acid (6), an ester component of the bitter-tasting natural products amarogentin and amaroswerin, was synthesized in six steps in 13.6% overall yield. Its N-acetyl cysteamine thiol ester (9) and its coenzyme A thiol ester (8), a likely biosynthetic precursor of the amarums, were also prepared. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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