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Kandis, Hayati/0000-0001-9151-6050 WOS: 000293479500020 Background: Postoperative strictures, which are still serious problems of tracheal surgery, are caused by an inflammatory reaction with subsequent edema and granulation tissue formation. Taking this into consideration, we have designed a study in which tenoxicam (potent, non-steroidal, anti-inflammatory drug) was used after a tracheal surgery in rats. Methods: Fourteen female Wistar rats were randomly divided into two groups (tenoxicam and control group) with equal numbers. Ketamine-xylazine anesthesia was performed in the rats. A vertical incision on the anterior tracheal wall, including the third to fifth cartilaginous rings, was performed and closed primarily with an interrupted suture technique using 4/0 absorbable suture. The tenoxicam group was administered 0.5 mg/kg/day tenoxicam and the control group was given 0.5 cc/day 0.9% NaCl via intraperitoneal route for 10 days beginning from the operation day. After two weeks, all animals were sacrificed under general anesthesia. Tracheas were excised, and a pathologist blindly evaluated the cases. The Mann-Whitney U-test was used for statistical analysis, and a value of p |
