Factors associated with tuberculosis-associated haemophagocytic syndrome: a multicentre case-control study
| Autor: | N. Lerolle, Lionel Galicier, J.-M. Molina, M. Laanani, F. Mougari, Sébastien Rivière, A. Jeblaoui, Cécile Goujard, V. Lalande, Laurence Fardet, O Lambotte, Elie Azoulay, J-L Meynard, Paul Coppo |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Tuberculosis HIV Infections Disseminated tb Lymphohistiocytosis Hemophagocytic Immunocompromised Host 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Intensive care Humans Medicine In patient business.industry Medical record Case-control study Admission rate medicine.disease 030104 developmental biology Infectious Diseases Case-Control Studies Female Risk of death business 030215 immunology |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 24:124-130 |
| ISSN: | 1027-3719 |
| Popis: | SETTING: Tuberculosis (TB) is a potential trigger of haemophagocytic syndrome (HS) but little is known about the features of TB-associated HS.OBJECTIVE: To assess the risk factors associated with HS in patients with TB.DESIGN: We performed a multicentre case-control study assessing the medical records of adult patients diagnosed with proven TB with (TB/HS+) or without (TB/HS–) associated HS.RESULTS: Twenty-one patients with TB/HS+ (24% women, median age, 37 years [IQR 30–48]) were included in the study. Eleven patients (52%) were infected with human immunodeficiency virus and seven patients (33%) were immunocompromised due to other reasons. TB was disseminated in 17 patients (81%). Compared with 50 control TB patients (TB/HS–), patients with TB/HS+ were more likely to be immunocompromised (86% vs. 18%; P < 0.001) and to present with disseminated TB (80% vs. 12%; P < 0.001). The outcome was poorer in patients with TB/HS+, with a higher admission rate to intensive care (71% vs. 0%; P < 0.001) and a higher risk of death (38% vs. 7%; P = 0.005).CONCLUSION: TB/HS+ occurred more likely in immunocompromised patients and severely impaired the prognosis of TB. Further studies are needed to devise therapeutic strategies for patients with TB/HS+. |
| Databáze: | OpenAIRE |
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