Systematic review and meta-analysis of flow cytometry in urinary tract infection screening
| Autor: | Zhi-De Hu, Qianqian Wang, Jian-Rong Zhang, Yan-Jun Shang, Weiwei Zhang, Yu-Lian Xu, Anmei Deng, Yan Chen, Mingli Gu |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Infection screening Bacteriuria Urinary system Clinical Biochemistry Colony Count Microbial Diagnostic accuracy Urinalysis Biology Biochemistry Leukocyte Count Internal medicine Leukocytes medicine Humans Urine sediment Intensive care medicine Receiver operating characteristic Quality assessment Biochemistry (medical) General Medicine Flow Cytometry Databases Bibliographic Confidence interval ROC Curve Area Under Curve Meta-analysis Urinary Tract Infections |
| Zdroj: | Clinica Chimica Acta. 424:90-95 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2013.05.014 |
| Popis: | Background Automated urine sediment analysis of white blood cells (WBCs) and bacteria is a promising approach for urinary tract infections (UTIs) screening. However, available data on their screening efficacy is inconsistent. Methods English articles from Pubmed, EMBASE, and Web of Science published before December 1, 2012 were analyzed. The Quality Assessment for Studies of Diagnostic Accuracy (QUADAS) tool was used to evaluate the quality of eligible studies. Performance characteristics of WBCs and bacteria (sensitivity, specificity, and other measures of accuracy) were pooled and examined by random-effects models. Results Nineteen studies containing 22,305 samples were included. Pooled sensitivities were 0.87 (95% confidence interval [CI], 0.86–0.89) for WBCs and 0.92 (95% CI, 0.91–0.93) for bacteria. Corresponding pooled specificities were 0.67 (95% CI, 0.66–0.68) for WBCs and 0.60 (95% CI, 0.59–0.61) for bacteria. Areas under the summary receiver operating characteristics curves were 0.87 and 0.93 for WBCs and bacteria, respectively. The major limitation of eligible studies was that enrolled subjects were often not representative of clinical patient populations in which UTI would be suspected. Conclusions WBC and bacterial measurements by the UF-100 and UF-1000i are useful indicators in UTI screening; however, the performances of these systems should be rigorously evaluated by additional studies. |
| Databáze: | OpenAIRE |
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