Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes

Autor: Nicolle Kränkel, Johann Bauersachs, Karin Weissenborn, Xinmin S. Li, Arash Haghikia, Udo Bavendiek, Aiden Haghikia, David Schmidt, Thomas G. Liman, Zeneng Wang, Weifei Zhu, Stanley L. Hazen, Kristina Sonnenschein, Nils Bledau, Friederike Zimmermann, Markus M. Heimesaat, Matthias Endres, Daniela Fraccarollo, Ulf Landmesser, Christian Widera
Rok vydání: 2018
Předmět:
0301 basic medicine
Antigens
Differentiation
T-Lymphocyte
Male
metabolism [Stroke]
Trimethylamine N-oxide
etiology [Cardiovascular Diseases]
Monocytes
Brain Ischemia
chemistry.chemical_compound
Recurrence
Risk Factors
physiology [Gastrointestinal Microbiome]
Choline
complications [Stroke]
Prospective Studies
Stroke
Hazard ratio
complications [Brain Ischemia]
etiology [Death
Sudden
Cardiac]
Cardiovascular Diseases
CD4 Antigens
CD6 antigen
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
metabolism [Brain Ischemia]
CD14
trimethyloxamine
blood [Methylamines]
Article
Proinflammatory cytokine
immunology [Monocytes]
03 medical and health sciences
Methylamines
Antigens
CD
Diabetes mellitus
Internal medicine
medicine
Animals
Humans
ddc:610
Inflammation
Cholesterol
business.industry
medicine.disease
Gastrointestinal Microbiome
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
Death
Sudden
Cardiac
chemistry
business
metabolism [Monocytes]
Zdroj: Arteriosclerosis, thrombosis, and vascular biology 38(9), 2225-2235 (2018). doi:10.1161/ATVBAHA.118.311023
ISSN: 1524-4636
DOI: 10.1161/ATVBAHA.118.311023
Popis: Objective— Gut microbiota–dependent metabolites, in particular trimethylamine N -oxide (TMAO), have recently been reported to promote atherosclerosis and thrombosis. Here, we examined for the first time the relation of TMAO and the risk of incident cardiovascular events in patients with recent first-ever ischemic stroke in 2 independent prospective cohorts. Moreover, the link between TMAO and proinflammatory monocytes as a potential contributing factor for cardiovascular risk in stroke patients was studied. Approach and Results— In a first study (n=78), higher TMAO plasma levels were linked with an increased risk of incident cardiovascular events including myocardial infarction, recurrent stroke, and cardiovascular death (fourth quartile versus first quartile; hazard ratio, 2.31; 95% CI, 1.25–4.23; P P P =0.04). A significant correlation was also found between TMAO levels and percentage of proinflammatory intermediate CD14 ++ CD16 + monocytes ( r =0.70; P high monocytes were higher than in the chow-fed control group (choline: 9.2±0.5×10 3 per mL versus control: 6.5±0.5×10 3 per mL; P 3 per mL; P Conclusions— The present study demonstrates for the first time a graded relation between TMAO levels and the risk of subsequent cardiovascular events in patients with recent prior ischemic stroke. Our data support the notion that TMAO-related increase of proinflammatory monocytes may add to elevated cardiovascular risk of patients with increased TMAO levels.
Databáze: OpenAIRE
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