Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer
| Autor: | Jiang Wu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pluripotent Stem Cells
Transcriptional Activation Chromosomal Proteins Non-Histone Neurogenesis Protein subunit ATP-dependent chromatin remodeling Biophysics Biochemistry DNA-binding protein Chromatin remodeling Epigenesis Genetic Mice Adenosine Triphosphate Neoplasms Animals Humans Chromatin structure remodeling (RSC) complex Transcription factor biology Chemistry Muscles Tumor Suppressor Proteins DNA Helicases Gene Expression Regulation Developmental Nuclear Proteins Heart General Medicine Chromatin Assembly and Disassembly Molecular biology Actins SWI/SNF Chromatin Cell biology DNA-Binding Proteins Disease Models Animal Protein Subunits Immune System biology.protein human activities Transcription Factors |
| Zdroj: | Acta Biochimica et Biophysica Sinica. 44:54-69 |
| ISSN: | 1672-9145 |
| Popis: | Mammalian SWI/SNF like Brg1/Brm associated factors (BAF) chromatin-remodeling complexes are able to use energy derived from adenosine triphosphate (ATP) hydrolysis to change chromatin structures and regulate nuclear processes such as transcription. BAF complexes contain multiple subunits and the diverse subunit compositions provide functional specificities to BAF complexes. In this review, we summarize the functions of BAF subunits during mammalian development and in progression of various cancers. The mechanisms underlying the functional diversity and specificities of BAF complexes will be discussed. |
| Databáze: | OpenAIRE |
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