Lower serum levels of IL-13 is associated with increased carotid intima-media thickness in old age subjects
| Autor: | Michele Francesco Croce, Patrizia Mecocci, Sara Ercolani, Alfredo Villa, Marta Baroni, Lucia Paolacci, Roberta Cecchetti, Virginia Boccardi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Aging medicine.medical_specialty Blood Pressure Overweight Systemic inflammation Gastroenterology Carotid Intima-Media Thickness Body Mass Index 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Aged Retrospective Studies Ultrasonography Inflammation Aged 80 and over Interleukin-13 business.industry Smoking Retrospective cohort study Marker Atherosclerosis Blood pressure Intima-media thickness Cohort Female Animal studies Geriatrics and Gerontology medicine.symptom business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Aging clinical and experimental research. 32(7) |
| ISSN: | 1720-8319 |
| Popis: | Cardiovascular diseases due to atherosclerosis represent the major cause of disability and mortality in old age subjects. The atherosclerotic process is linked to a low grade of systemic inflammation with the involvement of many cytokines and inflammatory proteins. Among them, evidence from animal studies suggests that IL-13 has a protective property. However, the role of IL-13 in the pathogenesis of atherosclerosis in humans is still unknown. With this study, we aim to investigate a potential association between IL-13 and carotid intima-media thickness (IMT) in old age subjects. This is a retrospective study conducted among 79 old age subjects (over 75 years old). All subjects underwent IMT assessment by high-resolution B-mode ultrasonography and IL-13 measurement in serum by ELISA. Subjects (41 M/38F) had a mean age of 81.0 ± 4.5 years and were mostly overweight. Stratifying the whole cohort by IMT thickness (IMT ≤ 0.9, n = 17; IMT ≥ 1 and ≤ 1.3, n = 50; IMT ≥ 1.4, n = 12) among the main variables explored, only BMI and triglycerides differed among groups, having subjects with higher IMT significantly higher BMI and lower triglycerides. Serum IL-13 levels significantly differed among groups having subjects with IMT ≥ 1.4 lower levels as compared to other groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink