Polymorphisms of theTRPV2andTRPV3genes associated with fibromyalgia in a Korean population
| Autor: | Chung-Il Joung, Seung-Jae Hong, Hyoun-Ah Kim, Seong-Ho Kim, Hyun-Sook Kim, Hye-Soon Lee, Ji Hyun Lee, Seong-Kyu Kim, Sang-Hyon Kim, Dong-Jin Park, Seong-Su Nah, Shin-Seok Lee, Yeon-Ah Lee |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Fibromyalgia Genotype TRPV Cation Channels Single-nucleotide polymorphism Polymorphism Single Nucleotide TRPV 03 medical and health sciences 0302 clinical medicine Rheumatology Republic of Korea Humans Medicine Genetic Predisposition to Disease Pharmacology (medical) Allele Gene Polymorphism Genetic business.industry Haplotype Case-control study Middle Aged medicine.disease Cross-Sectional Studies 030104 developmental biology Haplotypes Case-Control Studies Immunology Female business 030217 neurology & neurosurgery |
| Zdroj: | Rheumatology. 55:1518-1527 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objective Researchers continue to gather evidence that transient receptor potential vanilloid (TRPV) channels contribute towards pain signalling pathways. However, it is unknown whether polymorphisms of the TRPV gene are associated with FM. For the first time, we investigated the association between the polymorphisms of the TRPV2 and TRPV3 genes, FM susceptibility and the severity of the symptoms. Methods A total of 409 patients with FM and 423 controls were enrolled from 10 medical centres that participated in the Korean nationwide FM survey. The alleles and genotypes at three positions [rs3813768(C > G), rs8121(C > T) and rs1129235(C > A)] in the TRPV2 gene and two positions [rs7216486 (G > A) and rs395357(C > T)] in the TRPV3 gene were genotyped. Results The frequencies of the alleles and genotypes of individual TRPV2 and TRPV3 genes were not significantly associated with FM susceptibility. However, the GTA haplotype of TRPV2 showed a defence against FM susceptibility (P = 0.035). In addition, polymorphisms of TRPV3 were associated with symptom severity in FM patients. The single nucleotide polymorphism rs395357 of TRPV3 was associated with the scores of the Brief Fatigue Inventory (P = 0.017) in FM patients. Furthermore, haplotypes of TRPV3 were associated with the Brief Fatigue Inventory and the 36-item Short-Form Health Survey mental health summary scores (P = 0.036). Conclusion This study was the first to evaluate the associations of TRPV gene polymorphisms with FM. Our results suggest that certain TRPV2 haplotypes may have a protective role against FM and that some genotypes and haplotypes of TRPV3 contribute towards the symptoms of FM. |
| Databáze: | OpenAIRE |
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