Short communication: Influence of active tuberculosis on chemokine and chemokine receptor expression in HIV-infected persons
| Autor: | Sudha Subramanyam, Kaustuv Nayak, Jagadish Chandra Bose, Soumya Swaminathan, Luke Elizabeth Hanna |
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| Rok vydání: | 2005 |
| Předmět: |
Chemokine
Receptors CXCR4 Tuberculosis Receptors CCR5 T cell Immunology HIV Infections Biology CCL5 Chemokine receptor Virology medicine CCL17 Humans Chemokine CCL4 Chemokine CCL5 Tuberculosis Pulmonary Chemokine CCL3 AIDS-Related Opportunistic Infections Macrophage Inflammatory Proteins medicine.disease CXCL2 Infectious Diseases medicine.anatomical_structure biology.protein XCL2 Receptors Chemokine Chemokines |
| Zdroj: | AIDS research and human retroviruses. 21(12) |
| ISSN: | 0889-2229 |
| Popis: | Tuberculosis (TB) is the major opportunistic infection of HIV-1-infected patients in developing countries. Concurrent infection with TB results in immune cells having enhanced susceptibility to HIV-1 infection, which facilitates entry and replication of the virus. Cumulative data from earlier studies indicate that TB provides a milieu of continuous cellular activation and irregularities in cytokine and chemokine circuits that favor viral replication and disease progression. To better understand the interaction of the host with HIV-1 during active tuberculosis, we investigated in vivo expression of the HIV-1 coreceptors, CCR5 and CXCR4, and circulating levels of the inhibitory beta-chemokines, macrophage inflammatory protein-1-alpha (MIP-1alpha), macrophage inflammatory protein-1-beta (MIP-1beta), and regulated upon activation T cell expressed and secreted (RANTES), in HIV-positive individuals with and without active pulmonary tuberculosis. We found a significant decrease from normal in the fraction of CD4+ T cells expressing CCR5 and CXCR4 in individuals infected with HIV. However, CCR5 and CXCR4 expression did not differ significantly between HIV patients with and without tuberculosis. Higher amounts of MIP-1alpha, MIP-1beta, and RANTES were detected in plasma of HIV-1-positive individuals, particularly those with dual infection, although the increase was not found to be statistically significant. |
| Databáze: | OpenAIRE |
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