Matched-Pair Comparison of Radioembolization Plus Best Supportive Care Versus Best Supportive Care Alone for Chemotherapy Refractory Liver-Dominant Colorectal Metastases
| Autor: | Bert Hildebrandt, Oliver Dudeck, Ricarda Seidensticker, Jens Ricke, Konrad Mohnike, Maciej Pech, E. Kettner, Patrick Kraus, Jörg Fahlke, Timm Denecke, Max Seidensticker, Holger Amthauer |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Oncology medicine.medical_specialty Nausea Salvage therapy Liver disease Internal medicine Humans Medicine Yttrium Radioisotopes Radiology Nuclear Medicine and imaging Survival rate Proportional Hazards Models Retrospective Studies Performance status business.industry Proportional hazards model Liver Neoplasms Hazard ratio Retrospective cohort study Middle Aged medicine.disease Microspheres Survival Rate Treatment Outcome Female medicine.symptom Colorectal Neoplasms Cardiology and Cardiovascular Medicine business |
| Zdroj: | CardioVascular and Interventional Radiology. 35:1066-1073 |
| ISSN: | 1432-086X 0174-1551 |
| DOI: | 10.1007/s00270-011-0234-7 |
| Popis: | This study was designed to evaluate overall survival after radioembolization or best supportive care (BSC) in patients with chemotherapy-refractory liver-dominant metastatic colorectal cancer (mCRC). This was a matched-pair comparison of patients who received radioembolization plus BSC or BSC alone for extensive liver disease. Twenty-nine patients who received radioembolization were retrospectively matched with a contemporary cohort of >500 patients who received BSC from 3 centers in Germany. Using clinical databases, patients were initially matched for prior treatments and tumor burden and then 29 patients were consecutively identified with two or more of four matching criteria: synchronous/metachronous metastases, tumor burden, increased ALP, and/or CEA >200 U/ml. Survival was calculated from date of progression before radioembolization or BSC by using Kaplan–Meier analysis. Of 29 patients in each study arm, 16 pairs (55.2%) matched for all four criteria, and 11 pairs (37.9%) matched three criteria. Patients in both groups had a similar performance status (Karnofsky index, median 80% [range, 60–100%]). Compared with BSC alone, radioembolization prolonged survival (median, 8.3 vs. 3.5 months; P |
| Databáze: | OpenAIRE |
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