Potent inhibitors of LpxC for the treatment of Gram-negative infections

Autor:	Matthew David Doroski, Joel T. Arcari, Mark S. Plummer, Andrea Marra, Thomas M. Harris, Justin I. Montgomery, Usa Reilly, Carol A. Menard, Michael D. Huband, Anthony Marfat, Jinshan Michael Chen, Christy Thoma, Karen L. Leach, John P. O'Donnell, Seung Won Chung, Loren M. Price, Joseph A. Abramite, Charlene R. Desbonnet, Eric B. McElroy, Veerabahu Shanmugasundaram, Michael Melnick, Shenping Liu, Matthew Frank Brown, Mark C. Noe, Joseph S. Warmus, Juntyma J. Engtrakul, Daniel P. Uccello, Donn G. Wishka, Robert M. Oliver, Rose Barham, Joseph Penzien, Jonathan L. Doty, John D. Knafels, Ye Che, Lisa Mullins, Elizabeth M. Collantes
Rok vydání:	2011
Předmět:	Models Molecular Stereochemistry Molecular Conformation Sulfides Crystallography X-Ray Hydroxamic Acids Amidohydrolases chemistry.chemical_compound Mice Structure-Activity Relationship Pharmacokinetics Catalytic Domain Drug Discovery Drug Resistance Bacterial Animals Pseudomonas Infections Sulfones Gram Hydroxamic acid Phenyl Ethers Biphenyl Compounds Hydrogen Bonding Stereoisomerism Anti-Bacterial Agents Rats chemistry Pseudomonas aeruginosa Molecular Medicine Selectivity
Zdroj:	Journal of medicinal chemistry. 55(2)
ISSN:	1520-4804
Popis:	In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcf3eac90ca18e20f4de1258188335d https://pubmed.ncbi.nlm.nih.gov/22175825 Zobrazit plný text záznamu