Sequence variation in the L1 gene of human papillomavirus type 16 from Africa
| Autor: | Anna-Lise Williamson, Edward P. Rybicki, J. E. Ramesar |
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| Rok vydání: | 1995 |
| Předmět: |
Genes
Viral Molecular Sequence Data Uterine Cervical Neoplasms Cervix Uteri Biology Cervical intraepithelial neoplasia Virus Polymorphism (computer science) Virology Carcinoma medicine Humans Point Mutation Amino Acid Sequence Gene Peptide sequence Antigens Viral Papillomaviridae Genetics Viral Structural Proteins Polymorphism Genetic Point mutation Nucleic acid sequence General Medicine medicine.disease Uterine Cervical Dysplasia Female Epitope Mapping |
| Zdroj: | Archives of virology. 140(10) |
| ISSN: | 0304-8608 |
| Popis: | A 297 bp fragment of the HPV 16 L1 gene was sequenced from 35 isolates originating from normal cervical scrapes, cervical intraepithelial neoplasia biopsies and cervical carcinoma biopsies from South African women. A total of six point mutations that differed from the prototype HPV 16 sequence were detected in various combinations, giving rise to six distinct types of variants. Only one of the isolates had a sequence identical to the prototype. Our results indicate that the HPV L1 gene is conserved and there is no evidence that specific viral HPV L1 variants are associated with specific pathology. |
| Databáze: | OpenAIRE |
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