Electrolytic ablation as an adjunct to liver resection: experimental studies of predictability and safety
| Autor: | G. J. Finch, Simon A. Wemyss-Holden, Guy J. Maddern, Ashley R. Dennison, P. De La M. Hall |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Necrosis Swine medicine.medical_treatment Resection Metastasis Electrolytes Predictive Value of Tests medicine Animals Aspartate Aminotransferases Gamma-glutamyltransferase Electrodes biology business.industry Liver Neoplasms Alanine Transaminase gamma-Glutamyltransferase Ablation medicine.disease Effective dose (pharmacology) Surgery Alanine transaminase biology.protein Female medicine.symptom business Pig liver |
| Zdroj: | The British journal of surgery. 89(5) |
| ISSN: | 0007-1323 |
| Popis: | Background Combined liver resection and local ablation may offer the only chance of cure to patients with liver metastases who are presently deemed unresectable because of a single awkwardly placed metastasis. By definition, such a metastasis is often close to a major vein. An ablative technique is needed that is both predictable and safe in such a circumstance. Methods Electrolytic liver lesions were created in 21 pigs using platinum electrodes, connected to a direct current generator. Both electrolytic ‘dose’ and electrode separation were varied to produce different sized lesions. The ‘dose’ was correlated with the volume of necrosis and any vascular damage was determined histologically. Results There was a significant (P < 0·001) correlation between the electrolytic ‘dose’ and the volume of liver necrosis. For a given ‘dose’ the volume of necrosis was less when the electrodes were together, rather than separated. Liver enzymes were only transiently deranged. There were no significant vascular injuries. Conclusion Predictable and reproducible necrosis is produced by electrolysis in the pig liver. The treatment appears to cause little or no damage to immediately adjacent liver or major vascular structures and, when combined with resection, may offer the chance of a cure to many patients who are currently unresectable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text