Catechol-O-methyltransferase Val158Met polymorphism moderates anterior cingulate volume in posttraumatic stress disorder

Autor: Steven H. Woodward, Xiaoyan Lin, Stephan Eliez, Joachim Hallmayer, R. Jay Schulz-Heik, Marie Schaer, Danny G. Kaloupek
Rok vydání: 2010
Předmět:
Oncology
Adult
Male
medicine.medical_specialty
Genotype
Psychometrics
Catechol O-Methyltransferase/genetics
Catechol O-Methyltransferase
behavioral disciplines and activities
Amygdala
Gyrus Cinguli
Methionine/genetics
Functional Laterality
Stress Disorders
Post-Traumatic
ddc:616.89
Methionine
Stress Disorders
Post-Traumatic/genetics/pathology
Polymorphism (computer science)
Internal medicine
mental disorders
medicine
Humans
Allele
Psychiatry
Iraq War
2003-2011
Biological Psychiatry
Anterior cingulate cortex
Analysis of Variance
Catechol-O-methyl transferase
Gyrus Cinguli/pathology
Valine
Iraq War
2003
Valine/genetics
Middle Aged
Magnetic Resonance Imaging
ddc:616.8
stomatognathic diseases
medicine.anatomical_structure
nervous system
Frontal lobe
Vietnam
Female
Analysis of variance
Psychology
psychological phenomena and processes
Zdroj: Biological Psychiatry, Vol. 70, No 11 (2011) pp. 1091-6
ISSN: 1873-2402
0006-3223
Popis: Background Posttraumatic stress disorder (PTSD) is associated with structural and functional compromise of the anterior cingulate cortex (ACC), which may in turn be associated with impairment of its ability to regulate the amygdala. The Val158Met polymorphism in the catechol- O -methyltransferase gene, which substantially influences dopamine inactivation in the frontal lobe in general and in ACC in particular, may moderate ACC integrity in PTSD. Methods We tested this hypothesis in a sample of Vietnam and Persian Gulf War veterans who experienced substantial military operational stress, including 51 who met criteria for PTSD and 48 matched controls who did not. Results Participants with PTSD were previously reported to have smaller ACC volumes than controls in this sample. A novel repeated-measures analysis of variance was conducted with PTSD diagnosis, Val158Met genotype, and their interaction predicting left and right ACC volume. Genotype was not directly related to ACC volume, but it did significantly interact with the PTSD diagnosis. The difference in ACC volume between the participants without PTSD and participants with PTSD was greater among individuals homozygous for the Val allele than among carriers of the Met allele. This finding was driven largely by the right ACC. Analyses of Caucasian-only, non–Caucasian-only, and male-only subsamples indicated similar patterns. Conclusions Our findings suggest Val158Met genotype moderates the effect of PTSD-related processes on right ACC volume.
Databáze: OpenAIRE
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