Nanocomposites drug delivery systems for the healing of bone fractures
| Autor: | Khairi M. S. Fahelelbom, Ghulam Murtaza, Akram Ashames, Muhammad Ijaz, Jianxian Chen, Manal Ali Buabeid |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
media_common.quotation_subject Pharmaceutical Science Parathyroid hormone 02 engineering and technology Bone healing Bioinformatics 030226 pharmacology & pharmacy Nanocomposites Fractures Bone 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Animals Humans Medicine media_common Fracture Healing Diphosphonates business.industry Cartilage Bone Cements Bone Marrow Stem Cell Hydrogels Bone fracture 021001 nanoscience & nanotechnology medicine.disease medicine.anatomical_structure Self-healing hydrogels Drug delivery Nanoparticles Bone Remodeling 0210 nano-technology business |
| Zdroj: | International Journal of Pharmaceutics. 585:119477 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2020.119477 |
| Popis: | The skeletal system is fundamental for the structure and support of the body consisting of bones, cartilage, and connective tissues. Poor fracture healing is a chief clinical problem leading to disability, extended hospital stays and huge financial liability. Even though most fractures are cured using standard clinical methods, about 10% of fractures are delayed or non-union. Despite decades of progress, the bone-targeted delivery system is still restricted due to the distinctive anatomical bone features. Recently, various novel nanocomposite systems have been designed for the cell-specific targeting of bone, enhancing drug solubility, improving drug stability and inhibiting drug degradation so that it can reach its target site without being removed in the systemic circulation. Such targeting systems could consist of biological compounds i.e. bone marrow stem cells (BMSc), growth factors, RNAi, parathyroid hormone or synthetic compounds, i.e. bisphosphonates (BPs) and calcium phosphate cement. Hydrogels and nanoparticles are also being employed for fracture healing. In this review, we discussed the normal mechanism of bone healing and all the possible drug delivery systems being employed for the healing of the bone fracture. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect