The involvement of sigma1 receptors in donepezil-induced rescue of hippocampal LTP impaired by beta-amyloid peptide
| Autor: | Olga V. Popova, P D Rogozin, Elena I. Solntseva, N.A. Kapai, Vladimir G. Skrebitsky |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Agonist medicine.drug_class Morpholines Long-Term Potentiation Population Pharmacology Piperidines mental disorders medicine Haloperidol Animals Receptors sigma Donepezil Rats Wistar education CA1 Region Hippocampal education.field_of_study Amyloid beta-Peptides PRE-084 Chemistry General Neuroscience Antagonist Long-term potentiation Peptide Fragments Rats Acetylcholinesterase inhibitor Indans Cholinesterase Inhibitors medicine.drug |
| Zdroj: | Brain Research Bulletin. 106:56-61 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2014.06.002 |
| Popis: | Donepezil is a potent acetylcholinesterase inhibitor used for the treatment of Alzheimer's disease (AD). Additional therapeutically relevant target for donepezil is sigma1 receptor (Sig1-R). Beta-amyloid peptide (Aβ) is believed to contribute to the pathogenesis of AD. In our previous work (Kapai et al., 2012), we have shown that donepezil antagonizes the suppressive action of Aβ(1-42) on long-term potentiation (LTP) in rat hippocampal slices. The purpose of the present study was to determine whether Sig1-R is involved into the mechanisms of donepezil action. For this purpose, we have tested whether agonist of Sig1-R PRE-084 mimics, and antagonist of Sig1-R haloperidol abolishes the effect of donepezil. Population spikes (PSs) were recorded from the pyramidal layer of the CA1 region of rat hippocampal slices. Drugs were applied by addition to the perfusate starting 15 min before and ending 5 min after the tetanus. In the control group, the amplitude of PS 30 min post-tetanus reached 153±10%. Aβ (200 nM) markedly suppressed the LTP magnitude or even caused the suppression of baseline PS (82±8%, P |
| Databáze: | OpenAIRE |
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