The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family
| Autor: | Simon Collier, Paul N. Adler, Jae Hwan Goo, Woo Jin Park, David Gubb, Jeiwook Chae, Maengjo Kim, Jeannette Charlton |
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| Rok vydání: | 1999 |
| Předmět: |
Frizzled
animal structures Transcription Genetic Polarity (physics) Amino Acid Motifs Molecular Sequence Data Protocadherin Biology Receptors G-Protein-Coupled Cell Adhesion Animals Drosophila Proteins Wings Animal Amino Acid Sequence RNA Messenger Molecular Biology Gene Body Patterning Genetics Cadherin Cell Polarity Chromosome Mapping Gene Expression Regulation Developmental Membrane Proteins Cadherins Phenotype Frizzled Receptors Clone Cells Transmembrane domain Drosophila melanogaster Essential gene Multigene Family Mutation Insect Proteins Developmental Biology Hair Signal Transduction |
| Zdroj: | Development (Cambridge, England). 126(23) |
| ISSN: | 0950-1991 |
| Popis: | The tissue polarity genes control the polarity of hairs, bristles and ommatidia in the adult epidermis of Drosophila. We report here the identification of a new tissue polarity gene named starry night (stan). Mutations in this essential gene alter the polarity of cuticular structures in all regions of the adult body. The detailed polarity phenotype of stan on the wing suggested that it is most likely a component of the frizzled (fz) pathway. Consistent with this hypothesis, stan appears to be downstream of and required for fz function. We molecularly cloned stan and found that it encodes a huge protocadherin containing nine cadherin motifs, four EGF-like motifs, two laminin G motifs, and seven transmembrane domains. This suggests that Stan functions in signal reception, perhaps together with Fz. |
| Databáze: | OpenAIRE |
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