Effect of acetate and propionate on calcium absorption from the rectum and distal colon of humans
| Autor: | Trinidad P. Trinidad, Lilian U. Thompson, Tom Wolever |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Colon Medicine (miscellaneous) chemistry.chemical_element Rectum Polyethylene glycol Absorption (skin) Acetates Sodium Chloride Calcium chemistry.chemical_compound Internal medicine Mole medicine Humans Calcium metabolism chemistry.chemical_classification Nutrition and Dietetics Hydrogen-Ion Concentration Endocrinology medicine.anatomical_structure Intestinal Absorption chemistry Propionate Female Propionates Distal colon |
| Zdroj: | The American Journal of Clinical Nutrition. 63:574-578 |
| ISSN: | 0002-9165 |
| Popis: | To determine the effects of acetate and propionate on calcium absorption from the human distal colon and rectum, six healthy human subjects were given rectal infusions containing 50 mmol CaCl2/L on four separate occasions. Addition of 56.3 mmol acetate/L, 18.7 mmol propionate/L, or acetate and propionate together increased calcium disappearance (expressed as the change in the ratio of calcium to polyethylene glycol) from -5.5 +/- 1.4 to -22.6 +/- 2.8, -23.2 +/- 3.2, and -19.7 +/- 4.6, respectively; P0.05. To determine the effects of different acetate and propionate concentrations, six different subjects were studied further. The effects of 18.7 or 56.3 mmol acetate/L on calcium absorption were the same as those of 18.7 mmol propionate/L (-15.7 +/- 1.4), and less than those of 56.3 mmol propionate/L (-20.3 +/- 2.4, P0.05). We conclude that both acetate and propionate enhance calcium absorption from the human distal colon, but that propionate has a greater effect at higher concentrations. Further studies are needed to determine the mechanism of calcium absorption from the colon. |
| Databáze: | OpenAIRE |
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