Dynamic Neutrophil-Lymphocyte Ratios Predict Short-term Prognostic Outcome of Thrombolysis in Patients with Acute Ischemic Stroke
Autor: | Jiamin Shen, Yiyun Weng, Chenguang Yang, Guangyong Chen, Jingyu Hu, Shengqi Li, Honghao Huang, Yufan Gao, Wenjing Pan, Xuerong Huang, Junli Ren, Haojie Qiu, Fangyue Sun |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Neurology Time Factors Neutrophils medicine.medical_treatment Lymphocyte Toxicology Outcome (game theory) Brain Ischemia 03 medical and health sciences 0302 clinical medicine Fibrinolytic Agents Modified Rankin Scale Predictive Value of Tests Internal medicine medicine Humans In patient Neurochemistry Thrombolytic Therapy Lymphocytes Acute ischemic stroke Aged Ischemic Stroke business.industry General Neuroscience Thrombolysis Middle Aged Prognosis 030104 developmental biology medicine.anatomical_structure Treatment Outcome Cardiology Female business 030217 neurology & neurosurgery Follow-Up Studies |
Zdroj: | Neurotoxicity research. 39(5) |
ISSN: | 1476-3524 |
Popis: | The main purpose of this study was to investigate the dynamic changes of neutrophils-lymphocytes ratios (NLRs) in patients with acute ischemic stroke (AIS) and their relationships with 3-month prognostic outcomes. Two hundred ninety-one patients with AIS were included in this study, followed up for 3 months. At admission, 1 and 7 days after recombinant tissue plasminogen activator (r-tPA) injection, blood samples were obtained. Outcome events included excellent outcome, good outcome, and death defined as modified Rankin Scale (mRS) scores of 0–1, 0–2, and 6 respectively. NLRs measured in admission and 7 days after r-tPA treatment were associated with prognosis outcome after 3 months. Twenty-four-hour NLR is an excellent indicator in forecasting (excellent outcome’s the areas under the curve (AUC) = 0.725; good outcome AUC = 0.742; death AUC = 0.759). In addition, we were surprised to find that dynamic increase in NLR within 24 h is significantly related to excellent and good outcomes. Twenty-four-hour NLR is related to the severity of AIS and poor prognosis, which can help early risk stratification. We can predict the prognosis of AIS more accurately. Compared with previous studies, our study has shown the dynamic changes of NLR and its relationship with NIHSS and multiple prognostic. |
Databáze: | OpenAIRE |
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