Peptidoglycan Composition of Vancomycin-ResistantEnterococcus faecium
| Autor: | Boudewijn L. M. de Jonge, Sandra Handwerger, Douglas A. Gage |
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| Rok vydání: | 1996 |
| Předmět: |
Microbiology (medical)
Enterococcus faecium Immunology Peptide Peptidoglycan Muramoylpentapeptide Carboxypeptidase Spectrometry Mass Fast Atom Bombardment Biology Microbiology chemistry.chemical_compound Vancomycin Asparagine Amino Acids Vancomycin resistant Enterococcus faecium Pharmacology chemistry.chemical_classification Drug Resistance Microbial biochemical phenomena metabolism and nutrition Fast atom bombardment biology.organism_classification Anti-Bacterial Agents Amino acid Molecular Weight chemistry Biochemistry Genes Bacterial Lactates Composition (visual arts) Plasmids |
| Zdroj: | Microbial Drug Resistance. 2:225-229 |
| ISSN: | 1931-8448 1076-6294 |
| DOI: | 10.1089/mdr.1996.2.225 |
| Popis: | Muropeptide composition of peptidoglycan isolated from isogenic vancomycin-resistant and -sensitive Enterococcus faecium strains was analyzed by reverse-phase high-performance liquid chromatography combined with amino acid and fast atom bombardment mass spectrometric analyses. Peptidoglycan of the sensitive and resistant strains was the same and was composed of tri- and tetrapeptides stem peptide subunits with or without aspartate or asparagine substitutions on the e-amino group of the lysine residue. Thus, the synthesis of lactate-terminating peptidoglycan precursors in vancomycin-resistant E. faecium did not affect the chemical composition of peptidoglycan. |
| Databáze: | OpenAIRE |
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