Cyclic Dimeric Guanosine Monophosphate: Activation and Inhibition of Innate Immune Response
| Autor: | Tao Cui, Baoqiang Yang, Zheng-Guo He, Huaixing Cang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Innate immune system Membrane Proteins biochemical phenomena metabolism and nutrition Lipocalin Siderocalin Immunity Innate Cell biology DEAD-box RNA Helicases 03 medical and health sciences chemistry.chemical_compound Cytosol 030104 developmental biology 0302 clinical medicine Immune system Lipocalin-2 030228 respiratory system chemistry Host-Pathogen Interactions Guanosine monophosphate Second messenger system Extracellular Humans Immunology and Allergy Cyclic GMP |
| Zdroj: | Journal of Innate Immunity. 11:242-248 |
| ISSN: | 1662-8128 1662-811X |
| DOI: | 10.1159/000492679 |
| Popis: | Cyclic dimeric guanosine monophosphate (c-di-GMP) is a universally conserved second messenger that contributes to the pathogenicity of numerous bacterial species. In recent years, growing evidence has shown that bacterial extracellular c-di-GMP can interact with the innate immune system and regulate host immune responses. This review summarizes our current understanding on the dual roles of bacterial c-di-GMP in pathogen-host interaction: activation of the antibacterial innate immune response through the cytosolic surveillance pathway and inhibition of innate immune defense for iron restriction. |
| Databáze: | OpenAIRE |
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