Are there differences in oxidative stress and inflammatory processes between the autogenous and reactive subtypes of obsessive-compulsive disorder? A controlled cross-sectional study
| Autor: | Ferdi Köşger, Gülcan Güleç, Semra Yigitaslan, Melis Danışman Sonkurt, Ali Ercan Altınöz, Altan Eşsizoğlu |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Cross-sectional study Beck Anxiety Inventory RC435-571 medicine.disease_cause autogenous behavioral disciplines and activities Antioxidants 03 medical and health sciences 0302 clinical medicine Obsessive compulsive Internal medicine mental disorders Obsessive-compulsive disorder Humans oxidative stress Medicine Inflammation Psychiatry biology Aryldialkylphosphatase Interleukin-6 business.industry Beck Depression Inventory Paraoxonase PON1 humanities Interleukin-10 inflammatory process 030227 psychiatry Psychiatry and Mental health Antioxidant capacity C-Reactive Protein Cross-Sectional Studies biology.protein reactive business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Brazilian Journal of Psychiatry v.44 n.2 2022 Brazilian Journal of Psychiatry (São Paulo. 1999. Online) Associação Brasileira de Psiquiatria (ABP) instacron:ABP Brazilian Journal of Psychiatry, Volume: 44, Issue: 2, Pages: 171-177, Published: 23 JUN 2021 Brazilian Journal of Psychiatry, Issue: ahead, Published: 23 JUN 2021 Brazilian Journal of Psychiatry (2021) Brazilian Journal of Psychiatry n.ahead 2021 Revista Brasileira de Psiquiatria |
| ISSN: | 1809-452X 1516-4446 |
| DOI: | 10.1590/1516-4446-2021-1740 |
| Popis: | Objective: To date, no study has investigated whether autogenous and reactive obsessive-compulsive disorder (OCD) types are different entities in terms of oxidative stress and inflammatory processes. The aim of this study is to compare them in terms of these features. Methods: The study was conducted in subjects with reactive OCD (n=19), autogenous OCD (n=14), and a control group (n=17). All participants were non-smokers. Sociodemographic data were collected and the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Obsessive Beliefs Questionnaire (OBQ), and Overvalued Ideas Scale (OVIS) were administered. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-10 (IL-10), paraoxonase (PON1), total oxidant status (TOS), and total antioxidant status (TAS) were measured. Results: There were no significant differences in TAS, TOS, or oxidative stress index (OSI) between the OCD and control groups. PON1 and hs-CRP levels were higher in the OCD group, whereas IL-6 and IL-10 levels were lower. Comparison across the three groups revealed no differences in TAS, TOS, OSI, or PON1 levels; however, hs-CRP was significantly higher while IL-6 and IL-10 were significantly lower in the reactive group compared to controls. Conclusion: Our results show that, although inflammatory processes may play a role in OCD, the autogenous and reactive subtypes do not differ from each other in these respects. The classification of OCD into autogenous and reactive subtypes should be reevaluated. |
| Databáze: | OpenAIRE |
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