The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions
| Autor: | Andrew M. Hanby, Catherine Duggan, P Londesborough, Linda Lee Ho, Jack Cuzick, George Terry |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Ca FHIT EGFR Mammary gland Breast Neoplasms Biology Malignancy Polymerase Chain Reaction Sensitivity and Specificity Breast Diseases Proliferating Cell Nuclear Antigen medicine Atypia PCNA Humans skin and connective tissue diseases Molecular Diagnostics neoplasms Oligonucleotide Array Sequence Analysis CIS Staining and Labeling Carcinoma in situ Carcinoma Ductal Breast medicine.disease Immunohistochemistry Acid Anhydride Hydrolases Neoplasm Proteins Proliferating cell nuclear antigen ErbB Receptors Gene Expression Regulation Neoplastic body regions Carcinoma Intraductal Noninfiltrating medicine.anatomical_structure Oncology biology.protein RNA Female Breast disease BBD |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6603512 |
| Popis: | Immunohistochemical staining for FHIT and PCNA proteins was carried out in 451 breast lesions showing nonproliferative benign breast disease (BBD) (n=263), proliferative BBD without atypia (n=128), proliferative BBD with atypia (n=11), carcinoma in situ (n=15) or invasive carcinoma (n=34) and for EGFR protein in a subset of 71 of these cases. FHIT underexpression was not detected in nonproliferative lesions, but occurred in 2% of proliferative BBD without atypia, 10% proliferative BBD with atypia, 27% of carcinoma in situ and 41% of invasive carcinoma, which suggests that it could be useful in assessing those carcinoma in situ lesions (ductal, DCIS and lobular, LCIS) that are more likely to progress to malignancy. Preliminary microarray comparisons on DCIS and invasive carcinoma samples dissected from formalin-fixed paraffin sections showed a consistent downregulation of two previously identified FHIT-related genes, caspase 1 and BRCA1 in lesions underexpressing FHIT. |
| Databáze: | OpenAIRE |
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