Prognostic role of lactate on mortality in younger and older patients with cardio-respiratory failure admitted to an acute intensive care unit
| Autor: | David Della-Morte, Gianluca Testa, Salvatore Russo, Domenico Bonaduce, Pasquale Abete, Emiliano Assante di Panzillo, Gaetano Gargiulo, Francesco Di Grezia, Francesco Cacciatore |
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| Přispěvatelé: | Di Grezia, Francesco, Di Panzillo, Emiliano Assante, Russo, Salvatore, Gargiulo, Gaetano, Della-morte, David, Testa, Gianluca, Cacciatore, Francesco, Bonaduce, Domenico, Abete, Pasquale |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Aging Pediatrics medicine.medical_specialty Multivariate analysis Settore MED/09 - Medicina Interna Prognosi Intensive Care Unit Reproducibility of Result Predictive Value of Test law.invention 03 medical and health sciences 0302 clinical medicine Elderly Older patients Predictive Value of Tests law medicine Humans Hospital Mortality Lactic Acid 030212 general & internal medicine Acute Coronary Syndrome Mortality Aged Acidosis Lactate concentration Geriatrics gerontology business.industry Lactate Reproducibility of Results Cardiorespiratory fitness Middle Aged Prognosis Intensive care unit Hospitalization Intensive Care Units Italy Acidosis Lactic Female Geriatrics and Gerontology medicine.symptom Respiratory Insufficiency business 030217 neurology & neurosurgery Human |
| Popis: | BACKGROUND AND AIM: Acidosis is able to induce negative changes of different organs that increase progressively with aging. At present it is not known whether the levels of lactate may differently influence the prognosis of younger and older patients. Thus, the aim of this study is to evaluate the prognostic value of lactate levels after admission of younger and older patients to an acute intensive care unit. METHODS: Younger (2.5 mmol/L at the admission was higher in the older than in the younger patients (42.4 vs. 20.3 %, p < 0.01 and 57.8 vs. 31.9 %, p < 0.01, respectively). Lactate level was higher in older than in the younger patients both at admission and after 24 h (3.9 ± 3.4 vs. 2.4 ± 2.2 mmol/L and 2.4 ± 2.0 vs. 1.4 ± 1.3 mmol, p < 0.01, respectively). Accordingly, multivariate analysis shows that lactate was predictive of mortality in younger (OR = 2.65, 95 % CI 1.62-5.24, p = 0.03) and even more in the older (OR = 4.74, 95 % CI 2.10-6.70, p < 0.01) patients. CONCLUSIONS: Lactate concentration increase is associated with increased mortality in younger patients but, even more so, in older patients admitted to an acute intensive care unit. These results confirm the experimental evidence showing acidosis has a greater effect of leading to organ failure and higher mortality with increasing age. |
| Databáze: | OpenAIRE |
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