Colonization dynamics of Streptococcus pneumoniae in a remote African population: A prospective cohort study
| Autor: | Arnaud Flamen, Mark van der Linden, Jonas Ehrhardt, Abraham Alabi, Frieder Schaumburg |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Serotype
030231 tropical medicine Population Microbial Sensitivity Tests medicine.disease_cause Pneumococcal Infections Microbiology Pneumococcal Vaccines 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Drug Resistance Bacterial Streptococcus pneumoniae medicine Humans Colonization Gabon Prospective Studies 030212 general & internal medicine Serotyping education education.field_of_study General Veterinary General Immunology and Microbiology business.industry Broth microdilution Public Health Environmental and Occupational Health Infant Anti-Bacterial Agents Penicillin Infectious Diseases Pneumococcal vaccine Molecular Medicine business medicine.drug |
| Zdroj: | Vaccine. 38:5413-5417 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2020.06.051 |
| Popis: | The aim of this study was to analyze the population dynamics of Streptococcus pneumoniae in a remotely living African Pygmy population. The same pygmy population (Gabon) was prospectively screened for nasopharyngeal S. pneumoniae colonization in 2011 (n = 103), 2013 (n = 104) and 2017 (n = 107). Non-duplicate isolates (n = 126) were serotyped and tested for antimicrobial resistance (broth microdilution). At the three sampling time points, resistance rates were highest for tetracycline (36–58%), followed by penicillin (parenteral, meningitis-breakpoints, 6–39%) and chloramphenicol (3–15%). The majority of isolates was non-typeable (NT, n = 18/126, 14.3%) followed by serotype 6B (n = 17/126, 13.5%), 21 and 15A (n = 9/126, 7.1%, each). The distribution of serotypes was highly dynamic as only three serotypes (14, 17F, NT) were detected during all three visits. Resistance rates and serotypes of nasopharyngeal S. pneumoniae markedly changed in the remote Babongo population. This rapid change in serotypes could challenge the selection of pneumococcal vaccine. |
| Databáze: | OpenAIRE |
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