The effect of nifedipine on myocardial perfusion and metabolism in systemic sclerosis. A positron emission tomographic study
| Autor: | Bernard Amor, Bernard Maziere, Christian Loc'h, Denis Duboc, Georges Strauch, André Kahan, André Syrota, Charles J. Menkes, Christian Crouzel, François Guerin |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Fluorine Radioisotopes medicine.medical_specialty Systemic disease Nifedipine medicine.medical_treatment Immunology Potassium Radioisotopes Vasodilation Deoxyglucose Rheumatology Fluorodeoxyglucose F18 Coronary Circulation Internal medicine medicine Animals Humans Immunology and Allergy Pharmacology (medical) Chemotherapy Scleroderma Systemic medicine.diagnostic_test business.industry Myocardium Heart Middle Aged medicine.disease Positron emission tomography Cardiovascular agent Cardiology Female business Nuclear medicine Perfusion Emission computed tomography Tomography Emission-Computed medicine.drug |
| Zdroj: | Arthritis & Rheumatism. 34:198-203 |
| ISSN: | 1529-0131 0004-3591 |
| Popis: | We assessed the effect of nifedipine on myocardial perfusion and metabolism in 9 patients with systemic sclerosis, using positron emission tomography with a perfusion tracer (potassium-38) and a metabolic tracer (18F-fluorodeoxyglucose [18FDG]). Nifedipine, 20 mg 3 times daily for 1 week, induced a significant increase in 38K myocardial uptake, a significant decrease in 18FDG myocardial uptake, and a significant increase in the myocardial 38K: 18FDG ratio. These results indicate that the increase in myocardial perfusion is associated with modifications in myocardial energy metabolism, which probably result from a beneficial anti-ischemic effect of nifedipine in patients with systemic sclerosis. |
| Databáze: | OpenAIRE |
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