Tolerance to hepatitis B antigen: a hypothesis for its termination with 'immune-RNA'
| Autor: | Kasturi R. Rao, A. B. Ibrahim, Rudi Schmid, Girish N. Vyas |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
HBsAg
Leukocyte migration Hepatitis B Surface Antigens General Medicine Hepatitis B Biology medicine.disease Virology General Biochemistry Genetics and Molecular Biology Hepatitis B Antigens Immune system Antigen Immunity Immunology medicine Immune Tolerance Humans RNA General Pharmacology Toxicology and Pharmaceutics Viral hepatitis Immunologic Tolerance |
| Zdroj: | Life sciences. 15(2) |
| ISSN: | 0024-3205 |
| Popis: | Immunologic tolerance to hepatitis B antigen, evidenced by a lack of specific cellular and humoral immune response to HBsAg, produces a chronic carrier state which serves as an epidemiologic reservoir for the transmission of viral hepatitis type B. It is proposed that cell-mediated immunity transferred with immune-RNA may serve to terminate immunologic tolerance to hepatitis B antigen and abolish the carrier state. The efficacy and safety of ‘immune-RNA’ administration to chronic carriers can be validated by leukocyte migration inhibition techniques in vitro and in HBsAg positive chimpanzees in vivo . |
| Databáze: | OpenAIRE |
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