Hydrochlorothiazide abolishes the anti-atherosclerotic effect of quinapril
| Autor: | Sergio Tufik, Iel Lopes, Fah Fonseca, S.S.M. Ihara, Acc Carvalho, L. Pinto, E. P. Silva, Aav de Paola, Therezinha B. Paiva, Mco Izar, Kasinski N |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Arteriosclerosis Physiology Aorta Thoracic In Vitro Techniques medicine.disease_cause Gastroenterology chemistry.chemical_compound Hydrochlorothiazide Tetrahydroisoquinolines Physiology (medical) Internal medicine medicine.artery medicine Animals Drug Interactions Stroke Pharmacology Aorta medicine.diagnostic_test business.industry Cholesterol Quinapril medicine.disease Vasodilation Endocrinology medicine.anatomical_structure chemistry Rabbits Lipid profile business Oxidative stress medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 30:779-785 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1046/j.1440-1681.2003.03911.x |
| Popis: | Summary 1. Antihypertensive treatment has been demonstrated to result in persistent reductions in morbidity and mortality due to stroke. However, the coronary risk attributable to hypertension has been only partially reversed. We hypothesized that diuretics could have unfavourable effects on atherosclerosis. 2. New Zealand rabbits were fed a 0.5% cholesterol-enriched diet for 12 weeks, followed by a 0.1% cholesterol diet for another 12 weeks. During the last 12 week period, 40 animals were randomly assigned to one of four groups: (i) group I was the control group; (ii) group II received hydrochlorothiazide (10 mg/day); (iii) group III received quinapril (30 mg/day); and (iv) group IV was treated with hydrochlorothiazide (10 mg/day) plus quinapril (30 mg/day). 3. The treatments did not affect either the lipid profile or serum electrolytes and oxidative stress. However, endothelium-dependent vasorelaxation in isolated aortic rings was significantly improved with quinapril (group III) treatment (P |
| Databáze: | OpenAIRE |
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