Chemical entrapment and killing of insects by bacteria
| Autor: | Justin R. Nodwell, Louis Ho, Konstantin G. Iliadi, Gabrielle L. Boulianne, Martin Daniel-Ivad, Swathi P. Jeedigunta, Thomas R. Hurd, Craig A. Smibert, Jing Li |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Metabolite Science 030106 microbiology Microbial metabolism General Physics and Astronomy Biochemistry General Biochemistry Genetics and Molecular Biology Article Microbiology Actinobacteria 03 medical and health sciences chemistry.chemical_compound Metabolome Animals Anthracyclines lcsh:Science Spores Bacterial Larva Volatile Organic Compounds Multidisciplinary Camphanes biology Bacteria Cell Death fungi food and beverages General Chemistry biology.organism_classification Survival Analysis Chemical biology Streptomyces Spore Anti-Bacterial Agents 030104 developmental biology Drosophila melanogaster chemistry lcsh:Q human activities |
| Zdroj: | Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
| ISSN: | 2041-1723 |
| Popis: | Actinobacteria produce antibacterial and antifungal specialized metabolites. Many insects harbour actinobacteria on their bodies or in their nests and use these metabolites for protection. However, some actinobacteria produce metabolites that are toxic to insects and the evolutionary relevance of this toxicity is unknown. Here we explore chemical interactions between streptomycetes and the fruit fly Drosophila melanogaster. We find that many streptomycetes produce specialized metabolites that have potent larvicidal effects against the fly; larvae that ingest spores of these species die. The mechanism of toxicity is specific to the bacterium’s chemical arsenal: cosmomycin D producing bacteria induce a cell death-like response in the larval digestive tract; avermectin producing bacteria induce paralysis. Furthermore, low concentrations of volatile terpenes like 2-methylisoborneol that are produced by streptomycetes attract fruit flies such that they preferentially deposit their eggs on contaminated food sources. The resulting larvae are killed during growth and development. The phenomenon of volatile-mediated attraction and specialized metabolite toxicity suggests that some streptomycetes pose an evolutionary risk to insects in nature. Streptomyces bacteria produce metabolites with diverse biological activities. Here, Ho et al. show that some of these metabolites are volatile terpenes that attract fruit flies, while other metabolites can kill the insect’s larvae upon ingestion of bacterial spores. |
| Databáze: | OpenAIRE |
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