Spectrum of childhood Epstein-Barr virus-associated T-cell proliferations and bone marrow findings
| Autor: | Govind Bhagat, Bachir Alobeid, Nader Kim El-Mallawany, Deborah W. Sevilla, Suzy Alexander, Foxwell Emmons |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Epstein-Barr Virus Infections Lymphocytosis Adolescent T-Lymphocytes Hepatosplenomegaly Cell Separation Lymphoma T-Cell Pathology and Forensic Medicine Bone Marrow medicine T-cell lymphoma Humans In Situ Hybridization Fluorescence business.industry Plasmacytosis General Medicine Viral Load medicine.disease Flow Cytometry Pancytopenia Immunohistochemistry Lymphoproliferative Disorders Histiocytosis medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Immunology Female Bone marrow medicine.symptom Hemophagocytosis business |
| Zdroj: | Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 14(1) |
| ISSN: | 1093-5266 |
| Popis: | Systemic Epstein-Barr virus-positive (EBV+) T-cell lymphoproliferative disorder of childhood is a recently described entity. The majority of such cases have been reported from Asia, which suggests an underlying genetic predisposition. We analyzed the clinicopathologic characteristics of 5 children with EBV+ T-cell lymphoid proliferations evaluated and treated at our institute over a 2-year period. There were 3 males and 2 females of Latino ( n = 4) or Caucasian ( n = 1) heritage with a median age of 5 years (age range 2–18 years). All patients presented with EBV infection (acute, n = 4) with elevated serum EBV viral loads at the time of diagnosis and had systemic manifestations, including fever, hepatosplenomegaly, and pancytopenia. The bone marrow biopsies showed EBV+/CD8+ T-cell lymphocytosis in all patients, with variable degrees of histiocytosis, plasmacytosis, and hemophagocytosis. Interestingly, there was marked and consistent depletion of mature and precursor B cells in the marrow ( |
| Databáze: | OpenAIRE |
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