Sialochemical analysis in polytraumatized patients in intensive care units

Autor: João Armando Brancher, Aline Cristina Batista Rodrigues Johann, Renata Iani Werneck, Paulo Henrique Couto Souza, Amanda Rebeca da Silveira Wolf, Patrícia Vida Cassi Bettega, Danielle Nawcki, Marlene Barros, Luana Alves Tannous, Gabriele Muller Feustel, Kelly Aline Lima Nascimento, Sérgio Aparecido Ignácio, Maria Heloisa Madruga Chaves
Přispěvatelé: Veritati - Repositório Institucional da Universidade Católica Portuguesa
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Saliva
Physiology
Gastroenterology
Biochemistry
Hospitals
University
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Serum biomarkers
Medicine and Health Sciences
Medicine
Urea
APACHE
Multidisciplinary
APACHE II
Organic Compounds
Monosaccharides
Middle Aged
Hospitals
Body Fluids
Chemistry
Intensive Care Units
Blood
Creatinine
Physical Sciences
Female
Anatomy
0305 other medical science
Research Article
Adult
medicine.medical_specialty
Adolescent
Endocrine Disorders
Science
Carbohydrates
Positive correlation
03 medical and health sciences
Young Adult
Internal medicine
Diabetes mellitus
Intensive care
Diabetes Mellitus
Humans
Aged
030505 public health
business.industry
Multiple Trauma
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
030208 emergency & critical care medicine
Renal System
medicine.disease
N-Acetylneuraminic Acid
Health Care
Glucose
chemistry
Health Care Facilities
Metabolic Disorders
business
Biomarkers
Zdroj: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS ONE, Vol 14, Iss 10, p e0222974 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: The profiles of polytraumatized patients in intensive care units were characterized. Serum and salivary markers were compared with normality between Classes I and II of APACHE II and between periods of hospitalization; these results were correlated. This was a prospective study on saliva charts and collection (n = 70). Profile: male, 27 years old, blunt traumas and collisions. Serum parameters with normality: decrease in pH, creatinine at admission to Class I, and at 48 and 72 hours in both classes; K+ at 48 h in Class II; Ca+ on admission in both classes and at 72 h in Class I. Increase in urea at 72 h in Class II, glucose at all times and in all classes, and Ca+ at 48 h in both classes. Class II had high Na+ at 48 and 72 h compared to Class I. In Class I, creatinine reduction occurred in 48 h and 72 h compared to admission and an increase of Ca+ at 48 h with admission. In Class II, pH and Na+ increased at 48 h and 72 h compared to admission. K+ decreased from admission to 48 h and increased from 48 h to 72 h. Urea increased from 48 to 72 hours. Creatinine decreased from admission to 48 and 72 hours. Ca+ increased from admission to 48 hours and decreased from 48 to 72 hours. There was an increase in the saliva levels in both classes and times in relation to normality. There was an increase in urea at admission, glucose at 72 h, and Ca+ at 48 h in Class II compared with Class I. Class I urea increased from admission to 48 h and Ca+ decreased from admission to 48 h. Class II urea decreased from 48 h to 72 h. Strong or very strong positive correlation was identified between blood and creatinine saliva at all times and regular and negative Ca+ at 72 h. This study provides evidence that salivary and serum biomarkers can be used together to monitor the evolution of the clinical symptoms of ICU patients.
Databáze: OpenAIRE
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