The association of RANK gene C421T and C575T polymorphisms with bone mineral density in postmenopausal Turkish women
| Autor: | Volkan Turan, Kemal Öztekin, Asude Durmaz, Berrin Durmaz, Burak Durmaz, Ferda Ozkinay, Banu Isleten, Hüseyin Onay |
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| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2013 |
| Předmět: |
Genetic Markers
medicine.medical_specialty Genotype Turkey Osteoporosis Polymerase Chain Reaction Polymorphism Single Nucleotide RANK Exon Absorptiometry Photon Bone Density Internal medicine Bone mineral density Humans Medicine Polymorphism Allele frequency Osteoporosis Postmenopausal Aged Bone mineral Receptor Activator of Nuclear Factor-kappa B business.industry Haplotype Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Genotype frequency Postmenopause Logistic Models Haplotypes Case-Control Studies Linear Models Female business Blood drawing |
| Zdroj: | Archives of Gynecology and Obstetrics. 288:917-923 |
| ISSN: | 1432-0711 0932-0067 |
| DOI: | 10.1007/s00404-013-2831-y |
| Popis: | WOS: 000324635900028 PubMed ID: 23553199 To investigate the association between C421T polymorphism within exon 4, C575T polymorphism within exon 6 of the RANK gene and bone mineral density (BMD) variations in postmenopausal Turkish women. One hundred seventy-eight postmenopausal women (patients = 100 and controls = 78) who applied to Ege University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, for osteoporosis examination were analyzed. BMDs of the lumbar spine and femoral sites were measured. Patient and control groups were established based on their T-score values being above and/or below -1. After venous blood sampling, C421T and C575T polymorphisms of the RANK gene were assessed through PCR process following DNA extraction. Genotype frequencies for the C421T and C575T polymorphisms were compared between the control group and the patient group. No significant difference was detected between the two groups for both polymorphisms. There was also no significant difference between the control and patient groups in terms of the combined genotype (p = 0.752) and the combined haplotype analysis of the C421T and C575T polymorphisms (p = 0.723). In the control and patient groups separately, no significant differences in BMD values either at the femoral sites or at the lumbar spine were detected between the combined genotypes of the two polymorphisms. The genotypes, combined genotypes and allele frequencies of C421T and C575T polymorphisms of the RANK gene have not been found to be associated with BMD in Turkish women. Further studies including both sexes and more cases are required. Turkish Osteoporosis Society This study was supported financially by Turkish Osteoporosis Society. |
| Databáze: | OpenAIRE |
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