Inflammatory markers in postoperative cognitive dysfunction for patients undergoing total hip arthroplasty: a meta-analysis
| Autor: | Haihong Chen, Jincheng Lin, Guoliang Gong, Xiaowei Luo, Chunmei Fu, Weibin Zhong |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
medicine.medical_specialty business.industry Arthroplasty Replacement Hip Inflammation Publication bias medicine.disease Confidence interval Postoperative Complications Postoperative Cognitive Complications Strictly standardized mean difference Meta-analysis Internal medicine medicine Humans Biomarker (medicine) Cognitive Dysfunction Postoperative Period Geriatrics and Gerontology medicine.symptom business Postoperative cognitive dysfunction Biomarkers Cohort study |
| Zdroj: | Aging Clinical and Experimental Research. 34:277-288 |
| ISSN: | 1720-8319 |
| Popis: | Postoperative cognitive dysfunction (POCD) is a poorly understood disorder, very common even after total hip arthroplasty (THA). It is widely considered that inflammation response play a role in the pathogenesis of POCD. The aim of the present study was to investigate whether inflammation cytokine concentrations could serve as biomarkers for POCD in patients undergoing THA. A systematic search of databases was conducted to retrieve publications measuring circulating inflammatory markers of patients with and without POCD after THA. Inflammatory markers identified in more than two studies were pooled. The standardized mean difference (SMD) and the 95% confidence interval (95% CI) were calculated for each outcome. Fail-safe N statistics was calculated to estimate possible publication bias. The pooled incidence rate of POCD after THA by combining 11 cohort studies was 31%. A total of five inflammatory markers, CRP, S-100B, IL-1β, IL-6 and TNF-α, were assessed. Significantly higher pre-operative CRP (P = 0.012) and S-100B (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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