Biomonitoring and whole body cotton dosimetry to estimate potential human dermal exposure to semivolatile chemicals
| Autor: | Thomas Thongsinthusak, John H. Ross, Thomas G Osimitz, C. E. Bernard, Robert I. Krieger, Laura Fell, Travis M Dinoff |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Gossypium Insecticides integumentary system Epidemiology Public Health Environmental and Occupational Health Environmental Exposure Toxicology Administration Cutaneous Pollution Dermal exposure Clothing Xenobiotics Environmental chemistry Floors and Floorcoverings Biomonitoring Dosimetry Environmental science Humans Adsorption Chlorpyrifos Whole body Exercise |
| Zdroj: | Journal of exposure analysis and environmental epidemiology. 10(1) |
| ISSN: | 1053-4245 |
| Popis: | Current methods of estimating absorbed dosage (AD) of chemicals were evaluated to determine residue transfer from a carpet treated with chlorpyrifos (CP) to humans who performed a structured exercise routine. To determine the dislodgeability of residue, a California Department of Food and Agriculture (CDFA) roller was applied to a flat cotton cloth upon a treated carpet. Levels ranged from 0.06 to 0.99 microg CP/cm2. Cotton whole body dosimeters (WBD) were also used to assess residue transfer. The dosimeters retained 1.5 to 38 mg CP/person. Urine biomonitoring (3 days) for 3,5,6-trichloro-2-pyridinol (TCP) of persons who wore only swimsuits revealed a mean AD of 176 microg CP equivalents/person. The results show that the AD depends on the extent of contact transfer and dermal absorption of the residue. Default exposure assessments based upon environmental levels of chemicals and hypothetical transport pathways predict excessive exposure. The cotton WBD retains chemical residues and may be effectively used to predict dermal dose under experimental conditions. |
| Databáze: | OpenAIRE |
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