HIV and HCV co-infection: Situation at six French university hospitals in the year 2000

Autor: Claudine, Buffet-Janvresse, Hélène, Peigue-Lafeuille, Jacques, Benichou, Astrid, Vabret, Michel, Branger, Pascale, Trimoulet, Odile, Goria, Henri, Laurichesse, Abdelaziz, Abbed, Renaud, Verdon, Elisabeth, Bouvet, Marie-Edith, Lafon, Elisabeth, Dussaix, Louis, Cormerais, Michel, Dupon, Cécile, Henquell, Annie, Josse, Philippe, Lagoutte, Sylvie, Lariven, Sylvie, LeGac, Ghassan, Riachi, Renault, Verdon, Didier, Vittecoq
Rok vydání: 2002
Předmět:
Zdroj: Journal of Medical Virology. 69:7-17
ISSN: 1096-9071
0146-6615
DOI: 10.1002/jmv.10268
Popis: The aims of this study were to assess the sociodemographic, epidemiological, clinical, and biological characteristics of French patients co-infected with human immunodeficiency virus-hepatitis C virus (HIV-HCV), as well as the management of their HCV infection. Data on 509 HIV-HCV co-infected patients, followed up at six French University Hospitals, were collected using a questionnaire. Student's t-test, Pearson's chi-square, Fisher's exact, and Fisher-Freeman-Halton's exact tests were used. The mean age of the patients was 38.3 years, and the male to female sex ratio 2.08; 88% of patients were born in Metropolitan France, and 20% were dependent on health benefits; 74% were intravenous drug users and 14% blood or blood product recipients. Forty-seven percent were in CDC classification stage A, 18% had a CD4+ count of200, and 79% were undergoing current antiretroviral treatment. HCV RNA was positive in 84% (50% type 1, 13% untypable). Forty-four percent had normal alanine aminotransferase (ALT) levels, 24% alcohol consumption15 g/day, and 51% had undergone liver biopsy (10% of which had cirrhosis). Histological grade was not related to ALT level or CD4+ count. Overall, 40% of patients had been treated for HCV infection. HCV treatment was significantly associated with performance of liver biopsy, histological grade, ALT level, CD4+ count, Centers for Disease Control (CDC) classification, but not with age or alcohol consumption. Rate of early response to treatment was fifty percent among patients treated with bitherapy. Eighty-nine percent of all patients with previous or current anti-HCV treatment had undergone liver biopsy. In conclusion, despite the difficulties in managing hepatitis C in HIV-infected patients, almost one-half of all patients in this study had received anti-HCV treatment.
Databáze: OpenAIRE
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