New Insights into the Effects of Primary Hyperparathyroidism on the Cortical and Trabecular Compartments of Bone

Autor: Ego Seeman, Stephanie Boutroy, George Jerums, Dinaz Irani, Thuy D.T. Vu, Xiaofang Wang, Qingju Wang, Roger Zebaze, Ali Ghasem-Zadeh, Barbara C. Silva, John P. Bilezikian, Megan E. Romano, Julia Udesky, Natalie E. Cusano
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Popis: In primary hyperparathyroidism (PHPT), protracted elevation of serum parathyroid hormone (PTH) is held to be associated with cortical, but not trabecular, bone loss. However, an alternative explanation for the apparent preservation of trabecular bone is fragmentation of the cortex by intracortical remodeling. The cortical fragments resemble trabeculae and so may be erroneously included in the quantification of 'trabecular' bone density. To test this hypothesis, we compared bone microarchitecture in 43 patients with untreated PHPT (mean 62.9 years, range 31-84) with 47 healthy age-matched controls and 25 patients with surgically treated PHPT (63.6 years, 30-82). Images of the distal radius and tibia were acquired using high-resolution peripheral quantitative CT and analysed using StrAx1.0, a new software program that quantifies bone morphology in-vivo. Results were expressed as the mean number of standardized deviations (SD) from the age-specific mean (Z scores, mean±SEM). In subjects with PHPT, total tibial cortical area was reduced -0.26±0.08 SD; p=0.002). Cortical volumetric bone mineral density (vBMD) was reduced (-0.29±0.06 SD; p
Databáze: OpenAIRE
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