Presence of tumour capsule on contrast-enhanced CT is associated with improved outcomes of stereotactic body radiation therapy in hepatocellular carcinoma patients

Autor: Siu Hin Mak, Sean Man Natalie Wong, Wan Hang Keith Chiu, Chi Leung Chiang, Wing Ling Winnie Yip, Hoi Man Connie Ho, Sin Yu Cynthia Yeung, Ka Heng Mark Chan, Wan Yan Venus Lee, Ann Shing Francis Lee
Rok vydání: 2021
Předmět:
Zdroj: Strahlentherapie und onkologie. SPRINGER HEIDELBERG
ISSN: 1439-099X
0179-7158
Popis: PurposeStereotactic body radiation therapy (SBRT) is a novel local therapy for the treatment of hepatocellular carcinoma (HCC). While effective, there is currently noreliable radiological marker to guide patient selection. In this study, we investigated the prognostic value of capsule appearanceon contrast-enhanced computed tomography (CT) for patients undergoing SBRT. Materials and Methods Between 2006 and 2017, 156 consecutive patients with Child-Pugh score class A/B and HCC ≥5cm that underwent SBRT were retrospectively analysed. Baseline triple-phase CTs of the abdomen were reviewed for the presence of capsule appearances and correlated with objective response rate (ORR), overall survival (OS), and pattern of treatment failure. ResultsCapsule appearance on CT was present in 83 (53.2%) patients.It was associated with improved ORR by Response Evaluation Criteria in Solid Tumours (RECIST) (60.2% vs 24.7%; pConclusion Capsule appearance on CT could potentially be a non-invasive prognostic marker for selecting HCC patients undergoing SBRT. Larger cohort is warranted to validate our findings.
Databáze: OpenAIRE
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