Distribution of metastatic disease in the brain in relation to the hippocampus: a retrospective single-center analysis of 6064 metastases in 632 patients
| Autor: | Zi-Jing Wang, Qin Lin, Zhen-Yu He, Yongxiong Chen, Ming-Yue Rao, Juan Zhou, San-Gang Wu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Pathology Multivariate analysis hippocampus Single Center Metastasis Young Adult Risk Factors Internal medicine Odds Ratio medicine metastatic brain tumor Humans whole brain radiation therapy Neoplasm Metastasis Young adult Risk factor Aged Retrospective Studies Aged 80 and over Brain Neoplasms business.industry Age Factors Retrospective cohort study Odds ratio Middle Aged medicine.disease age Female Clinical Research Paper business Brain metastasis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.5828 |
| Popis: | This study aimed to investigate the patterns of brain metastasis and to explore the risk factors affecting hippocampus metastasis (HM). We retrospectively analyzed the clinical information of patients with metastatic disease in the brain. The associations between clinicopathologic variables with HM and peri-hippocampal metastasis (PHM) were evaluated in univariate and multivariate regression analyses. A total of 632 patients with 6064 metastatic lesions were recruited into the present study. Of these, 4.1% (26/632) of patients developed HM, and 5.5% (35/632) of patients developed PHM. Only 0.5% (31/6064) of metastatic lesions were located in the hippocampus and 0.6% (37/6064) were in the PHM. Age ≤60 years was an independent risk factor for HM (odds ratio [OR]: 2.602, 95% confidence interval [CI]: 1.115-6.076, P = 0.027) and PHM (OR: 2.555, 95%CI: 1.229-5.310, P = 0.012) in univariate and multivariate analyses. The hippocampus is a rare site of brain metastasis. Younger patients (age ≤60 years) had increased risk of developing HM and PHM. The current study provides the opportunity to investigate the clinical feasibility of hippocampal sparing whole brain radiation therapy, especially in older patients. |
| Databáze: | OpenAIRE |
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