Low Grade Inflammation in Juvenile Obesity and Type 1 Diabetes Associated with Early Signs of Atherosclerosis
| Autor: | Winfried Maerz, A. Griesl, Martin Borkenstein, Harald Mangge, L. Stroedter, Konrad Schauenstein |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Leptin
Male medicine.medical_specialty Adolescent Homocysteine Arteriosclerosis Carotid Artery Common Endocrinology Diabetes and Metabolism medicine.medical_treatment Asymptomatic Body Mass Index chemistry.chemical_compound Folic Acid Endocrinology Diabetes mellitus Internal medicine Internal Medicine medicine Humans Obesity Child Inflammation Type 1 diabetes C-Peptide business.industry Insulin Receptors Interleukin-2 General Medicine medicine.disease Vitamin B 12 C-Reactive Protein Diabetes Mellitus Type 1 chemistry Female medicine.symptom Tunica Intima business Body mass index |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 112:378-382 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-2004-821023 |
| Popis: | Background: Subclinical inflammation has been implicated in the initiation and/or progression of atherosclerosis. Diabetes mellitus and obesity are risk factors for atherosclerosis, and asymptomatic low grade inflammation occurs prior to overt vascular lesions in these patients. In contrast to adults, little information exists concerning low grade inflammation in young type 1 diabetes and juvenile obesity. Aim: To investigate low grade inflammation and immune activation in juvenile diabetes mellitus and obesity. Methods: hs-CRP, soluble interleukin-2 receptor (sIL-2R), C-peptide, insulin, cortisol, vitamin B12, folic acid, leptin, and homocysteine were determined in 148 patients with juvenile type 1 diabetes, 86 obese children and 142 normal weighted age-matched healthy controls. Intima-media thickness (IMT) and lumen diameter of both common carotid arteries (CCA) was measured by ultrasonography in 52 healthy pediatric controls, 10 diabetics, and 34 obese juveniles. Results: Serum hs-CRP was significantly elevated in patients with type 1 diabetes (p < 0.0001), and obese children (p < 0.0001) as compared to the control group. The obese juveniles (p < 0.0001) and the diabetics (p < 0.0001) showed significantly increased values for IMT of CAAs. Levels of homocysteine, sIL-2R, insulin, cortisol, vitamin B12, and folic acid did not differ from the controls. The elevation of hs-CRP was more pronounced in obesity as compared to type 1 diabetes (p < 0.0001), and the hs-CRP values correlated significantly with body mass index standard deviation score (BMI-SDS) values. Furthermore, the IMT and the luminal diameter of CCAs showed significant correlations with BMI-SDS values. Conclusion: A low grade inflammation as determined by serum hs-CRP is significantly increased in children with type 1 diabetes, and even more pronounced in apparently healthy juveniles with obesity. The increased IMT of CCAs strongly argues for an association between this low grade inflammation and early atherosclerotic vessel injury. |
| Databáze: | OpenAIRE |
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