Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599
| Autor: | Syriou Stavroula, Drakoulis Nikolaos, Dido Vassilakopoulou, Kotrotsou Maria, Kalampoki Vasiliki, Touloumis Charalampos |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Article Subject Single-nucleotide polymorphism Disease behavioral disciplines and activities Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype mental disorders medicine Psychiatry 030304 developmental biology 0303 health sciences business.industry Haplotype medicine.disease 3. Good health Endocrinology Increased risk Schizophrenia Clinical Study business 030217 neurology & neurosurgery rs4680 |
| Zdroj: | ISRN Psychiatry |
| ISSN: | 2090-7966 |
| Popis: | Schizophrenia, a severe psychiatric condition, is characterized by disturbances of cognition, emotion, and social functioning. The disease affects almost 1% of world population. Recent studies evaluating the role of catechol-O-methyltransferase enzyme (COMT) polymorphisms in the pathogenesis of schizophrenia have resulted in ambiguous findings. The current study examined the association of schizophrenia with three COMT polymorphisms, namely, rs737865, rs4680, and rs165599 in a Greek population. There was no significant association between schizophrenia and any of the three SNPs examined. However, haplotype analysis showed that cases have higher frequency of the T-A-A haplotype, and participants with that haplotype were at increased risk for developing schizophrenia (OR = 1.52; CL : 1.12–2.08; ). Furthermore, patients with schizophrenia displayed an excess of TC/AA/AA and the TT/AA/GA genotypes. Similarly a protective effect of TT/GG/GG and TT/GA/GG was suggested by our results. |
| Databáze: | OpenAIRE |
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