Clinical Characteristics of a Non-Alcoholic Fatty Liver Disease Population Across the Fibrosis Spectrum Measured by Magnetic Resonance Elastography: Analysis of Screening Data
| Autor: | Leona Plum-Mörschel, Anni Morsing, Paul D. Hockings, Mads Sundby Palle, Olivia Svolgaard, Anne Flint, Grit Andersen |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Liver Cirrhosis Male 030213 general clinical medicine medicine.medical_specialty Population Type 2 diabetes Gastroenterology Body Mass Index 03 medical and health sciences 0302 clinical medicine Fibrosis Non-alcoholic Fatty Liver Disease Internal medicine Medicine Humans Pharmacology (medical) Obesity education Original Research education.field_of_study medicine.diagnostic_test business.industry Fatty liver Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Magnetic resonance elastography Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Elasticity Imaging Techniques Female Steatohepatitis business Body mass index |
| Zdroj: | Advances in Therapy |
| ISSN: | 1865-8652 |
| Popis: | Introduction Non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases, is associated with liver-related complications and metabolic comorbidities. The phenotype is wide, ranging from simple steatosis to non-alcoholic steatohepatitis with advanced fibrosis. In this analysis of a phase 1 trial, clinical characteristics of screened subjects with NAFLD were studied according to the extent of fibrosis assessed using magnetic resonance elastography (MRE). Methods One hundred ninety-four subjects with body mass index (BMI) of 25–40 kg/m2 and suspected NAFLD were assessed by MRE and grouped by MRE thresholds as a proxy for fibrosis staging (groups 0–4). Data were summarized by group levels, and correlation analyses between MRE values and clinical parameters (including magnetic resonance imaging-proton density fat fraction) were performed. Results Most subjects had MRE values in the lower range (groups 0–1; N = 148). Type 2 diabetes (T2D) and BMI > 35 kg/m2 were more frequent in groups with higher than lower MRE values. Subjects in the highest MRE groups also tended to be older and have higher liver enzyme concentrations compared with lower MRE groups. No, or weak, correlations were found between MRE values and clinical parameters (all r values ≤ 0.45). Conclusions There was considerable variation and overlap in clinical characteristics across the spectrum of liver stiffness. Although groups with high MRE values generally included more subjects with T2D and obesity, and had higher age and concentrations of liver enzymes, the clinical characteristics did not strongly correlate with MRE scores in this population. Trial Registration Registered on Clinicaltrials.gov on November 29, 2017 (NCT03357380). |
| Databáze: | OpenAIRE |
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